刘全宏

一、个人简介

刘全宏，博士，教授，博士生导师，陕西省细胞生物学学会资深理事。主要从事声、光动力抗癌生物学机制、秦巴山区药用植物活性成份分析方面研究工作，主持国家自然科学基金和省部级科研项目6项，横向科研项目1项，参加国家自然科学基金、十二五科技支撑计划项目10多项，荣获陕西省科学技术奖二等奖、三等奖各1项，陕西高等学校科学技术奖一等奖2项。在国内外重要刊物上发表论文150余篇，其中SCI论文100多篇。

二、主要研究领域及兴趣

1. 声光动力治疗

2. 秦巴山区药用植物毒理分析

3. 敏化剂修饰及药物载体研究

三、承担的科研项目

1.主持国家自然科学基金面上项目，基于氧化应激-线粒体损伤研究声光动力治疗乳腺癌的作用机制，2016.1-2019.12，81571834。

2.主持国家自然科学基金面上项目，超声激活血卟啉诱导肿瘤细胞凋亡的细胞分子生物学机制研究，2003.1-2005.12，30270383。

3.主持国家自然科学基金面上项目，超声激活血卟啉抗肿瘤的细胞分子生物学机理研究，1999.1-2001.12，39870240。

4.主持陕西省自然科学基金项目，桦菌芝提取物活性成分分析及诱导肿瘤细胞凋亡机制探讨，2014.5-2016.4，2014JM4137。

5.主持教育部高等学校博士学科点专项科研基金项目：声动力诱导乳腺癌细胞自噬性死亡机制研究，2011.1-2013.12，20100202110006。

6.主持教育部骨干教师资助项目：超声激活血卟啉抗肿瘤途径研究，2011.1-2013.12。

四、代表性论文

1. Yixiang Li, Huanxiao An, Xiaobing Wang, Pan Wang*, Fei Qu, Yan Jiao, Kun Zhang, Quanhong Liu*. Ultrasound-triggered release of sinoporphyrin sodium from liposome-microbubble complexes and its enhanced sonodynamic toxicity in breast cancer. Nano Research, 2018, 11(2): 1038-1056.

2. Xiaolan Feng#, Yin Shi#, Lifen Xie, Kun Zhang, Xiaobing Wang, Quanhong Liu*, Pan Wang*. Synthesis, characterization, and biological evaluation of a porphyrin-based photosensitizer and its isomer for effective photodynamic therapy against breast cancer. Journal of Medicinal Chemistry, 2018, 61 (16): 7189-7201.

3. Pan Wang, Xiao Wang, Lun Ma, Sunil Sahi, Li Li, Xiaobing Wang, Qingqing Wang, Yujiao Chen, Wei Chen*, Quanhong Liu*. Nanosonosensitization by using copper-cysteamine nanoparticles augmented sonodynamic cancer treatment. Particle & Particle Systems Characterization, 2018, 35(4): 1700378.

4. Mingxing Zhang, Nan Du, Lu Wang, Xiaobing Wang, Yaping Xiao, Kun Zhang, Quanhong Liu*, Pan Wang*. Gynostrmma pentaphyllum seed oil which is rich in conjugated fatty acid can ameliorate lipid and glucose metabolism in type 2 diabetes mellitus mice. Food & Function, 2017, 8(10): 3696-3706.

5. Li Li#, Huiyu Wang#, Haiping Wang#, Lijun Li, Pan Wang, Xiaobing Wang*, Quanhong Liu*. Interaction and oxidative damage of DVDMS to BSA: a study on the mechanism of photodynamic therapy-induced cell death. Scientific Reports, 2017, 7: 43324.

6. Lu Wang, Min Pang, Xiaobing Wang, Pan Wang*, Yaping Xiao, Quanhong Liu*. Characteristics, composition, and antioxidant activities in vitro and in vivo of Gynostemma pentaphyllum (Thunb.) Makino seed oil. Journal of the Science of Food and Agriculture, 2017, 97(7): 2084-2093.

7. Lu Wang, Xiaobing Wang, Pan Wang, Yaping Xiao, Quanhong Liu*. Optimization of supercritical carbon dioxide extraction, physicochemical and cytotoxicity properties of Gynostemma pentaphyllum seed oil: A potential source of conjugated linolenic acids. Separation and Purification Technology, 2016, 159: 147-156.

8. Yixiang Li, Yuetao Zhou, Xiaobing Wang, Pan Wang, Yaping Xiao, Xiaoxia Cheng, Yanhua Zhang, Yilin Liu, Quanhong Liu*. Fruit extract from Pyropolyporus fomentarius（L. ex Fr.）Teng induces mitochondria-dependent apoptosis in leukemia cells but enhances immunomodulatory activities of splenic lymphocytes. Nutrition and Cancer, 2016, 68(4): 708-717.

9. Yixiang Li, Pan Wang, Xiyang Chen, Jianmin Hu, Yichen Liu, Xiaobing Wang*, Quanhong Liu*. Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells. Ultrasonics Sonochemistry, 2016, 33: 26-36.

10. Xiaobing Wang#, Jianmin Hu#, Pan Wang, Shaoliang Zhang, Yichen Liu, Wenli Xiong, Quanhong Liu*. Analysis of the in vivo and in vitro effects of photodynamic therapy on breast cancer by using a sensitizer, sinoporphyrin sodium. Theranostics, 2015, 5(7): 772-786.

五、获奖情况

1. 2014年获得陕西省科学技术奖三等奖，第三完成人。

2. 2014年获得陕西高等学校科学技术奖一等奖，第三完成人。

3. 2009年获得陕西省科学技术奖二等奖，第一完成人。

4. 2009年获得陕西高等学校科学技术奖一等奖，第一完成人。