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姓名：吴宏梅 |
职称/职务：副教授 |
电话： |
传真： |
电子信箱：hq8479@snnu.edu.cn |
研究方向：蛋白质修饰与疾病 |
办公地点： |
一、个人简介
吴宏梅，博士，副教授，博士生导师。2008年赴美，先后在贝勒医学院生化系和贝勒医学院细胞生物学系从事博士后研究，主要从事脂肪酸代谢和肿瘤的发生和转移机制研究。2015年至今为beat365官网登录入口副教授，教学上主要承担细胞生物学、细胞生物学实验课程、细胞信号转导与调控课程。科研上，现阶段主要进行蛋白质修饰与肿瘤的发生和转移的作用机制研究。 近年来主持国家自然科学基金2项，中央高校科研项目3项。相关研究成果发表在Cell death and differentiation、Journal of Biological Chemistry、Oncogene、Proc Natl Acad Sci USA.等国际刊物。
二、承担的科研项目
1.主持国家自然科学基金面上项目，MCAD及其SUMO修饰调控ERK/ZEB1通路影响三阴性乳腺癌侵袭和转移的作用与机制研究（2023.1-2026.12，82273395）
2.主持国家自然科学基金青年项目，肉碱棕榈酰转移酶1(CPT1)调控脂肪酸氧化代谢促进三阴性乳腺癌转移的机制研究（2016.1-2018.12，81502531）
3.主持中央高校基本科研业务费专项资金项目，SUMO抑制剂治疗急性髓系白血病的作用机制研究（2022.6-2024.5，GK202205009）
4.主持中央高校基本科研业务费专项资金项目，MCAD调控三阴性乳腺癌EMT进程的机制研究（2019.1-2020.12，GK201903066）
5.主持中央高校基本科研业务费专项资金项目，脂酰辅酶A脱氢酶(ACADs)调控三阴性乳腺癌转移的机制研究（2016.1-2017.12，GK201603064）
三、代表性论文
1. Qi Su, Xu Chen, Xing Ling, Danqing Li, Xiang Ren, Yang Zhao, Yanyan Yang, Yuhang Liu, Anqi He, Xinjie Zhu, Xinyi Yang, Wenbin Lu,Hongmei Wu*, Yitao Qi*. SUMOylation of Smad2 mediates TGF-β-regulated endothelial-mesenchymal transition.Journal of biological chemistry. 2023. 299(10):105244.
2. Xu Chen, Yuanyuan Qin, Yuhong Zhang, Xinyi Yang, Zhengcao Xing, Yajie Shen, Jinke Cheng, Edward Yeh, Hongmei Wu*, Yitao Qi*. SENP2-PLCβ4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.Cell death and differentiation.2022. 29(2):337-350.
3. Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T.H. Yeh, Hongmei Wu*, Yitao Qi*. SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels. Journal of biological chemistry. 2021. 297(4): 101183(1-14).
4. Yuhong Zhang, Xu Chen, Qiqi Wang, Congcong Du, Wenbin Lu, Hong Yuan, Zhenzhen Zhang, Danqing Li, Xing Ling, Xiang Ren, Yang Zhao, Qi Su, Zhengcao Xing, Yuanyuan Qin, Xinyi Yang, Yajie Shen, Hongmei Wu*, Yitao Qi*. Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology. Journal of molecular medicine. 2021. 99(12): 1797-1813.
5. Xu Chen, Yuanyuan Qin, Zhenzhen Zhang, Zhengcao Xing, Qiqi Wang, Wenbin Lu, Hong Yuan, Congcong Du, Xinyi Yang, Yajie Shen, Biying Zhao, Huanjie Shao, Xiaotong Wang,Hongmei Wu*, Yitao Qi*. Hyper-SUMOylation of ERG is essential for the progression of acute myeloid leukemia.Frontiers in molecular biosciences. 2021. 8: 652284(1-15).
6. Biying Zhao, Zhenzhen Zhang, Xu Chen, Yajie Shen, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Shanshan Zhang, Xiaojun Long, Yuhong Zhang, Siming An,Hongmei Wu*, Yitao Qi*. The important roles of protein SUMOylation in the occurrence and development of leukemia and clinical implications.Journal of Cellular Physiology. 2021.236 : 3466-3480.
7. Yuanyuan Qin, Hong Yuan, Xu Chen, Xinyi Yang, Zhengcao Xing, Yajie Shen, Wanying Dong, Siming An, Yitao Qi*,Hongmei Wu*.SUMOylation wrestles with the occurrence and development of breast cancer.Frontiers in oncology. 2021.11: 1-11.
8. Xu Chen, Yuhong Zhang, Qiqi Wang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen,Hongmei Wu*, Yitao Qi*. The function of SUMOylation and its crucial roles in the development of neurological diseases.The FASEB Journal. 2021. 35(4): e21510(1-17).
9. Xiaojun Long, Biying Zhao, Wenbin Lu, Xu Chen, Xinyi Yang, Jifang Huang, Yuhong Zhang, Siming An, Yuanyuan Qin, Zhengcao Xing, Yajie Shen,Hongmei Wu*, Yitao Qi*. The critical roles of the SUMO-specific protease SENP3 in human diseases and clinical implications.Frontiers in physiology.2020. 11 2020: 1-14.
10. Xu Chen, Shanshan Zhang, Jifang Huang, Wanying Dong, Hui Xiao, Huanjie Shao, Jinke Cheng,Hongmei Wu*, Yitao Qi*. Hyper-SUMOylation of K+ channels in sudden unexplained death in epilepsy: Isolation and primary culture of dissociated hippocampal neurons from newborn mice for subcellular localization.Methods in molecular biology.2018.1684: 63-71.
11. Hongmei Wu, Jiong Bi, Yan Peng, Lei Huo, Xiaobin Yu, Zhihui Yang, Yunyun Zhou, Li Qin, Yixiang Xu, Lan Liao, Yang Xie, Orla M. Conneely, Jos Jonkers and Jianming Xu. Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer.Oncotarget.2017; 8(33):54364-54377.
12. Hongmei Wu, Xu Chen, Jinke Cheng, Yitao Qi* SUMOylation and Potassium Channels: Links to Epilepsy and Sudden Death.Advances in Protein Chemistry and Structural Biology. 2016. 103: 295-321.
