董小明

一、个人简介

董小明，博士，硕士生导师。2017年7月毕业于天津大学，获得博士学位。2017年10月至2018年9月在芬兰奥卢大学从事博士后研究。2018.10至今在beat365官网登录入口任职，主要从事前列腺癌发生发展的分子机制研究。研究成果以第一作者或通讯作者主要发表在Oncogene，Stem Cell，Frontiers in Oncology，FASEB J和Cell signal等杂志上，此外，还在Cell, Advanced Science杂志上以共同作者发表研究性论文两篇。

二、主要研究领域及兴趣

1.前列腺癌的发病机制研究。

2.前列腺癌的临床药物筛选和风险预测。

三、承担的科研项目

1.国家自然科学基金面上项目，ITGA1在前列腺癌发生发展中的作用及机制研究，2020.01-2023.12，项目编号：81972417，在研，第一参与人。

2.陕西省自然科学基础研究计划一般项目（青年），GATA2与EEFSEC相互作用在前列腺癌中的作用机制研究，2020.01-2021.12，项目编号：2020JQ-430，已结题，主持。

3.陕西省自然科学基础研究计划一般项目（面上），前列腺癌中E2F1与TEAD1调控关系的研究，2020.1-2021.12，项目编号：2020JM-292，已结题，第一参与人。

4.中央高校基本科研业务费资助项目（一般项目），EDAG调节MDS红系祖细胞分化与凋亡的作用及机制研究，2019.01-2020.12，项目编号：GK201903061，已结题，主持。

四、代表性论文

1.Gao P*, Hao JL, Xie QW, Han GQ, Xu BB, Hu H, Sa NE, Du XW, Tang HL, Yan J,Dong XM*. PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer. Oncogene. 2022, May, 41(21):2945-2957.(IF: 9.867)

2.Dong XM, Zhang Q, Hao JL, Xie QW, Xu BB, Zhang P, Yang TL, Wei GH, Na R and Gao P*. Large multicohort study reveals a prostate cancer susceptibility allele at 5p15 regulating TERT via androgen signaling-orchestrated chromatin binding of E2F1 and MYC. Frontiers in Oncology. 2021, Nov 10, 11:754206. doi: 10.3389/fonc.2021.754206.(IF: 6.244)

3.Gao P#*, Dong XM#, Wang Y# and Wei GH*. Optimized CRISPR/Cas9-mediated single nucleotide mutation in adherent cancer cell lines. STAR Protoc. 2021, Mar, 2(2):100419.#co-first author (Cell旗下子刊)

4.Zhao Ke, Liu JF, Zhu YX,Dong XM, Yin RH, Liu X, Gao HY, Xiao FJ, Gao R, Wang Q, Zhan YQ, Yu M, Chen H, Ning HM, Zhang CB, Yang XM * and Li CY *. Hemgn protects hematopoietic stem and progenitor cells against transplantation stress through negatively regulating IFN-γ signaling. Advanced Science. 2022, Feb, 9(5):e2103838.(IF: 16.806)

5.Dong XM, Zhao K, Zheng WW, Xu CW, Zhang MJ, Yin RH, Gao R, Tang LJ, Liu JF, Chen H, Zhan YQ, Yu M, Ge CH, Gao HY, Li X, Luo T, Ning HM, Yang XM and Li CY. EDAG Mediates Hsp70 Nuclear Localization in Erythroblasts and Rescues Dyserythropoiesis in Myelodysplastic Syndrome. FASEB J. 2020, Jun, 34(6):8416-8427.(IF: 5.191)

6.Dong XM, Liu ED, Meng YX, Liu C, Bi YL, Wu HW, Jin YC, Yao JH, Tang LJ, Wang J, Li M, Zhang C, Yu M, Zhan YQ, Chen H, Ge CH, Yang XM and Li CY. Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination. Scientific Reports. 2016, Sep, 6:32710.(IF: 4.259)

7.Dong XM, Yin RH, Yang Y, Feng ZW, Ning HM, Dong L, Zheng WW, Tang LJ, Wang J,Jia YX, Jiang YN, Liu ED, Chen H, Zhan YQ, Yu M, Ge CH, Li CY, Yang XM. GATA-2 inhibits Transforming Growth Factor-β signaling pathway through interaction with Smad4. Cell signal. 2014, May, 26(5):1089–1097.(IF: 4.315)

8.Zheng WW#, Dong XM#, Yin RH, Xu FF, Ning HM, Zhang MJ, Xu CW, Yang Y, Ding YL, Wang ZD, Zhao WB, Tang LJ, Chen H, Wang XH, Zhan YQ, Yu M, Ge CH, Li CY and Yang XM. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cell. 2014, Aug, 32(8): 2278-2289.#co-first author (IF: 6.523)

9.Gao P#, Xia JH#, Sipeky C,Dong XM, Zhang Q, Yang Y, Zhang P, Cruz SP，Zhang K, Zhu J, Lee HM, Suleman S, Giannareas N, Liu S, The PRACTICAL consortium, Tammela T，Auvinen A，Wang XY, Huang QL, Wang L, Manninen A, Vaarala MH, Wang L, Schleutker J, Wei GH. Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus. Cell. 2018 Jul 26, 174(3):576-589. (IF: 41.582)

10.Zhao K, Zheng WW,Dong XM, Yin RH, Gao R, Li X, Liu JF, Zhan YQ, Yu M, Chen H, Ge CH, Ning HM, Yang XM, Li CY. EDAG promotes the expansion and survival of human CD34+ cells. PLoS One. 2018 Jan 11, 13(1):e0190794.

11.Liu C#, Liu ED#, Meng YX#, Dong XM, Bi YL, Wu HW, Jin YC, Zhao K, Li JJ, Yu M, Zhan YQ, Chen H, Ge CH, Yang XM, Li CY.Keratin 8 reduces colonic permeability and maintains gut microbiota homeostasis, protecting against colitis and colitis-associated tumorigenesis.Oncotarget. 2017 May 27. doi: 10.18632.

12.Wang KP, Zhang C, Zhang SG, Liu ED, Dong L, Kong XZ, Cao P, Hu CP, Zhao K, Zhan YQ,Dong XM, Ge CH, Yu M, Chen H, Wang L, Yang XM and Li CY. 3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis. Oxidative Medicine and Cellular Longevity. 2015(3):11-20.

13.Kong XZ, Yin RH, Ning HM, Zheng WW,Dong XM, Yang Y, Xu FF, Li JJ, Zhan YQ, Yu M, Ge CH, Zhang JH, Chen H, Li CY, Yang XM. Effects of THAP11 on erythroid differentiation and megakaryocytic differentiation of K562 cells. PLoS One. 2014, March, 9(3): e91557.

14.Zheng WW, Yang Y, Zhang MJ,Dong XM, Tang LJ, WangXH, Zhan YQ, Yu M, Ge CH, Ning HM, Li CY and Yang XM. Silencing of EDAG induces degradation of NPM1 and sensitivity to chemotherapeutic drug in acute myeloid leukemia patients. Progress in Biochemistry and Biophysics. 2013, 40(9): 877~886.

15.徐彬兵,郝敬兰,谢倩文,萨娜尔,王诗虞,杜晓文,卢海成,高平,石光耀,董小明.干涉EEFSEC抑制前列腺癌细胞的增殖、迁移和侵袭[J].南方医科大学学报, 2021, 41(12):1787-1794.

16.董小明, 郑巍薇,尹荣华,詹轶群,杨晓明,李长燕.利用ChIP-seq技术研究转录因子EDAG在全基因组的结合谱[J].中国生物化学与分子生物学报, 2013, 29(6): 578-584.

五、获奖情况

1. 2014年博士研究生国家奖学金

2. 2018年奥卢生物年度发现奖